2-hydroxy-4-methylquinoline
structural formula
| business number | 069q |
|---|---|
| molecular formula | c10h9no |
| molecular weight | 159.18 |
| label |
4-methyl-2(1h)-quinolone, 4-methyl-2-hydroxyquinoline, 4-methylquinolinone, 4-methyl-2-quinolinol, 4-methyl-2-quinolinol, 4-methylcarbostyril |
numbering system
cas number:607-66-9
mdl number:mfcd00006745
einecs number:210-139-0
rtecs number:none
brn number:118331
pubchem number:24895639
physical property data
physical property data:
1. character: needle-shaped crystal
2. melting point245℃
3. boiling point>360, 270℃（2.27kpa)
4. solubility: soluble in ethanol and hot water, slightly soluble in cold water, ether, chloroform and benzene
toxicological data
none
ecological data
3. ecological data:
1. other harmful effects: this substance may be harmful to the environment and should be harmful to water bodies. give special attention.
molecular structure data
5. molecular property data:
1、 molar refractive index:48.89
2、 molar volume (m3/mol):131.4
3、 isotonic specific volume (90.2k):357.9
4、 surface tension (dyne/cm):54.9
5, polarizability (10-24cm3 ):19.38
compute chemical data
1. reference value for hydrophobic parameter calculation (xlogp): 1.2
2. number of hydrogen bond donors: 1
3. number of hydrogen bond acceptors: 1
4. number of rotatable chemical bonds: 0
5. number of tautomers: 2
6. topological molecule polar surface area 29.1
7. number of heavy atoms: 12
8. surface charge: 0
9. complexity: 232
10. number of isotope atoms: 0
11. determine the number of atomic stereocenters: 0
12. uncertain number of atomic stereocenters: 0
13. determine the number of chemical bond stereocenters: 0
14.nothe number of stereocenters of certain chemical bonds: 0
15. the number of covalent bond units: 1
properties and stability
1. properties: acicular crystal.
storage method
storage:
seal the secret container and store it in a sealed main container in a cool place dry position.
synthesis method
2. preparation method: obtained by cyclization of acetoacetanilide in the presence of sulfuric acid. preheat concentrated sulfuric acid to 75℃, add acetoacetanilide in batches, and control the temperature to 70-75℃. after the addition is complete, raise the temperature to 95℃, response15minthen cool to65℃, pour the mixture into the water. after cooling, filter, wash the product with water and methanol, dry it with 95%the finished product is obtained by recrystallizing ethanol.
purpose
3. uses: used as organic synthesis intermediates.
