indomethacin indomethacin
structural formula
| business number | 0164 |
|---|---|
| molecular formula | c19h16clno4 |
| molecular weight | 357.79 |
| label |
indomethacin, anti-inflammatory indoleic acid, 1-p-chlorobenzoyl-5-methoxy-2-methylindoleacetic acid, indenaxin, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid |
numbering system
cas number:53-86-1
mdl number:mfcd00057095
einecs number:200-186-5
rtecs number:nl3500000
brn number:497341
pubchem number:24278173
physical property data
1. character:white crystal. sensitive to light.
2. density (g/ml,25/4℃): undetermined
3. relative vapor density (g/ml,air=1): undetermined
4. melting point (ºc):155℃（162℃）
5. boiling point (ºc,undetermined
6. boiling point (ºc,5.2kpa): undetermined
7. refractive index: undetermined
8. flashpoint (ºc): undetermined
9. specific optical rotation (º): undetermined
10. autoignition point or ignition temperature (ºc): undetermined
11. 2. molar volume (m3/mol) ：269.5
3. isotonic ratio(90.2k)：707.6
4. surface tension(dyne/cm)：47.4
5. polarizability(10-24cm3)：37.49
compute chemical data
1. reference value for hydrophobic parameter calculation (xlogp): none
2. number of hydrogen bond donors: 1
3. number of hydrogen bond acceptors: 4
4. number of rotatable chemical bonds: 4
5. number of tautomers: none
6. topological molecule polar surface area 68.5
7. number of heavy atoms: 25
8. surface charge: 0
9. complexity: 506
10. number of isotope atoms: 0
11. determine the number of atomic stereocenters: 0
12. uncertain number of atomic stereocenters: 0
13. determine the number of chemical bond stereocenters: 0
14. number of uncertain chemical bond stereocenters: 0
15. number of covalent bond units: 1
properties and stability
none
storage method
this product should be sealed in4preserve dry.
synthesis method
indomethacin is obtained by diazotization, reduction, acidification, hydrolysis and cyclization of p-aminoanisole.
purpose
for biochemical research. biosynthesis of prostaglandins. the it is an anti-inflammatory product with obvious antipyretic effects. it is mainly used for rheumatic arthritis, ankylosing spondylitis, osteoarthritis, etc. that are intolerant to salicylic acid drugs or have insignificant efficacy.
“>p-aminoanisole undergoes diazotization, reduction, acidification, hydrolysis and cyclization to obtain indomethacin.
purpose
for biochemical research. biosynthesis of prostaglandins. the it is an anti-inflammatory product with obvious antipyretic effects. it is mainly used for rheumatic arthritis, ankylosing spondylitis, osteoarthritis, etc. that are intolerant to salicylic acid drugs or have insignificant efficacy.
