acetamidozole 2-acetamido-5-nitrothiazole
structural formula
| business number | 03t1 |
|---|---|
| molecular formula | c5h5n3o3s |
| molecular weight | 187.18 |
| label |
2-acetamido-5-nitrothiazole, 2-acetamido-5-nitrothiazole, 5-nitro-2-acetilaminotiazolo, aromatic compounds |
numbering system
cas number:140-40-9
mdl number:mfcd00022438
einecs number:205-414-7
rtecs number:xj1570000
brn number:none
pubchem id:none
physical property data
1. physical property data
1.characteristics: white crystalline powder, slightly odorous, almost tasteless
2.melting point (℃): 264～266℃(decomposes ).
3.solubility: in sodium hydroxide(potassium)lye and ammonia moderately soluble, soluble in ethanol, slightly soluble in chloroform, slightly soluble in ether, almost insoluble in water
toxicological data
2. toxicological data:
1, acute toxicity: rat abdominal cavity ld50: >200 mg/kg;
rat orally ld50 ：>400 mg/kg;
rat subcutaneous ld: >3200 mg/kg;
orally administered to mice ld50 ：200 mg/kg;
mouse abdominal cavity ld50: >300 mg/kg;
mouse subcutaneous ld: >3200 mg/kg.
ecological data
3. ecological data:
1, other harmful effects: this substance may be harmful to the environment, special attention should be paid to water bodies.
molecular structure data
5. molecular property data:
1. molar refractive index:43.54
2. molar volume (m3/ mol):117.0
3. isotonic specific volume (90.2k): 343.8
4. surface tension (dyne/cm): 74.4
5. polarizability（10-24cm3):17.26
compute chemical data
1. reference value for hydrophobic parameter calculation (xlogp): none
2. number of hydrogen bond donors: 1
3. number of hydrogen bond acceptors: 5
4. number of rotatable chemical bonds: 1
5. number of tautomers: 5
6. topological molecule polar surface area 116
7. number of heavy atoms: 12
8. surface charge: 0
9. complexity: 205
10. number of isotope atoms: 0
11. determine the number of atomic stereocenters: 0
12. uncertain number of atomic stereocenters: 0
13. determine the number of chemical bond stereocenters: 0
14. number of uncertain chemical bond stereocenters: 0
15. number of covalent bond units: 1
properties and stability
stable under normal temperature and pressure.
storage method
stored sealed in a dry and cool place.
synthesis method
by2-aminothiazole is used as raw material.
purpose
3. isotonic specific volume (90.2k):343.8
4. surface tension (dyne/cm): 74.4
5. polarizability（10-24cm3):17.26
compute chemical data
1. reference value for hydrophobic parameter calculation (xlogp): none
2. number of hydrogen bond donors: 1
3. number of hydrogen bond acceptors: 5
4. number of rotatable chemical bonds: 1
5. number of tautomers: 5
6. topological molecule polar surface area 116
7. number of heavy atoms: 12
8. surface charge: 0
9. complexity: 205
10. number of isotope atoms: 0
11. determine the number of atomic stereocenters: 0
12. uncertain number of atomic stereocenters: 0
13. determine the number of chemical bond stereocenters: 0
14. number of uncertain chemical bond stereocenters: 0
15. number of covalent bond units: 1
properties and stability
stable under normal temperature and pressure.
storage method
stored sealed in a dry and cool place.
synthesis method
by2-aminothiazole is used as raw material.
purpose
it is suitable for oral treatment of trichomoniasis, and can also be used for the treatment of amoebic and intestinal bacterial infections.
tyle=”font-size: 10pt; color: #333333; font-family: 宋体; mso-ascii-font-family: ‘times new roman’; mso-hansi-font-family: ‘times new roman'”>applicable it is used for the oral treatment of trichomoniasis and can also be used to treat amoebic and intestinal bacterial infections.