safety data sheet (msds) for n,n-dimethylcyclohexylamine handling

Published by BDMAEE on 2025-04-30 | Permalink

safety data sheet (sds) for n,n-dimethylcyclohexylamine: a comprehensive guide

introduction

n,n-dimethylcyclohexylamine (dmcha, cas no. 98-94-2) is a tertiary amine widely utilized as a catalyst in polyurethane foam production, a chemical intermediate in various organic syntheses, and as an acid scavenger. due to its inherent chemical properties, dmcha presents potential hazards and requires careful handling and storage. this document provides a comprehensive overview of dmcha, encompassing its properties, hazards, handling procedures, safety precautions, and regulatory information. it serves as a valuable resource for individuals working with or handling dmcha to ensure safe and responsible practices. this sds aims to provide detailed information based on current scientific understanding and regulatory guidelines.

1. identification

chemical name: n,n-dimethylcyclohexylamine
synonyms: cyclohexylamine, n,n-dimethyl-; dimethylcyclohexylamine; n,n-dimethylcyclohexanamine
cas registry number: 98-94-2
ec number: 202-715-5
molecular formula: c₈h₁₇n
molecular weight: 127.23 g/mol
structural formula: (provide a chemical structure diagram description, e.g., a cyclohexane ring with a dimethylamino group (n(ch3)2) attached to one carbon atom.)
un number: un2264 (for shipping)
recommended use: catalyst, chemical intermediate, acid scavenger.
restrictions on use: use only as directed and in accordance with safety data sheet instructions.

2. hazard identification

dmcha is classified as a hazardous substance according to various international regulations. understanding the potential hazards is crucial for implementing appropriate safety measures.

ghs classification:
- acute toxicity, oral: category 4 (harmful if swallowed) ⚠️
- acute toxicity, dermal: category 4 (harmful in contact with skin) ⚠️
- acute toxicity, inhalation: category 4 (harmful if inhaled) ⚠️
- skin corrosion/irritation: category 1b (causes severe skin burns and eye damage) 🔥
- serious eye damage/eye irritation: category 1 (causes serious eye damage) 👀
- specific target organ toxicity – single exposure: category 3 (respiratory system irritation) 💨
hazard statements:
- h302: harmful if swallowed.
- h312: harmful in contact with skin.
- h314: causes severe skin burns and eye damage.
- h332: harmful if inhaled.
- h335: may cause respiratory irritation.
precautionary statements:
- general:
  - p101: if medical advice is needed, have product container or label at hand.
  - p102: keep out of reach of children.
  - p103: read carefully and follow all instructions.
- prevention:
  - p260: do not breathe dust/fume/gas/mist/vapors/spray.
  - p264: wash thoroughly after handling.
  - p270: do not eat, drink or smoke when using this product.
  - p271: use only outdoors or in a well-ventilated area.
  - p280: wear protective gloves/protective clothing/eye protection/face protection.
- response:
  - p301 + p330 + p331: if swallowed: rinse mouth. do not induce vomiting.
  - p303 + p361 + p353: if on skin (or hair): take off immediately all contaminated clothing. rinse skin with water [or shower].
  - p304 + p340: if inhaled: remove person to fresh air and keep comfortable for breathing.
  - p305 + p351 + p338: if in eyes: rinse cautiously with water for several minutes. remove contact lenses, if present and easy to do. continue rinsing.
  - p310: immediately call a poison center/doctor.
  - p363: wash contaminated clothing before reuse.
- storage:
  - p403 + p233: store in a well-ventilated place. keep container tightly closed.
  - p405: store locked up.
- disposal:
  - p501: dispose of contents/container in accordance with local/regional/national/international regulations.
other hazards:
- may be harmful to aquatic life with long lasting effects.
- vapors may form explosive mixtures with air.

3. composition/information on ingredients

ingredient	cas number	ec number	concentration (%)	classification
n,n-dimethylcyclohexylamine	98-94-2	202-715-5	≥ 99%	acute tox. 4 (oral, dermal, inhalation); skin corr. 1b; eye dam. 1; stot se 3 (resp. irrit.)

4. first-aid measures

general advice: immediately remove contaminated clothing. seek immediate medical attention.
inhalation: remove the affected person to fresh air. if breathing is difficult, administer oxygen. if breathing has stopped, perform artificial respiration. seek immediate medical attention.
skin contact: immediately flush skin with plenty of water for at least 20 minutes while removing contaminated clothing and shoes. seek immediate medical attention.
eye contact: immediately flush eyes with copious amounts of water for at least 30 minutes, holding eyelids apart to ensure thorough irrigation. remove contact lenses if present and easy to do. continue rinsing. seek immediate medical attention.
ingestion: do not induce vomiting. rinse mouth with water. if conscious, give small quantities of water to drink. never give anything by mouth to an unconscious person. seek immediate medical attention.
most important symptoms and effects, both acute and delayed: severe burns to the skin, eyes, and mucous membranes. inhalation may cause respiratory irritation, coughing, and difficulty breathing. ingestion may cause gastrointestinal irritation, nausea, vomiting, and abdominal pain.
indication of any immediate medical attention and special treatment needed: treat symptomatically and supportively. consider gastric lavage with activated charcoal if ingestion is recent and the patient is conscious. monitor for respiratory distress and treat accordingly.

5. fire-fighting measures

suitable extinguishing media: use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
unsuitable extinguishing media: do not use a solid water stream as it may spread the fire.
specific hazards arising from the chemical: vapors are heavier than air and may travel along the ground to a source of ignition and flash back. combustion may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides.
special protective equipment and precautions for fire-fighters: wear self-contained breathing apparatus (scba) and full protective clothing. cool fire-exposed containers with water spray. prevent runoff from fire control or dilution from entering sewers or waterways.

6. accidental release measures

personal precautions, protective equipment, and emergency procedures:
- evacuate personnel from the affected area.
- ensure adequate ventilation.
- wear appropriate personal protective equipment (ppe) as specified in section 8.
- avoid contact with skin, eyes, and clothing.
- avoid breathing vapors.
- remove all sources of ignition.
environmental precautions: prevent further leakage or spillage if safe to do so. do not let product enter drains, sewers, or waterways. inform the relevant authorities if environmental pollution occurs.
methods and materials for containment and cleaning up:
- contain the spill with absorbent material (e.g., sand, earth, vermiculite).
- collect the spilled material into suitable containers for disposal.
- neutralize residue with dilute acid (e.g., hydrochloric acid).
- wash the spill area with water.
- dispose of contaminated materials in accordance with local, regional, and national regulations.

7. handling and storage

precautions for safe handling:
- use only in well-ventilated areas.
- avoid contact with skin, eyes, and clothing.
- avoid breathing vapors.
- wear appropriate personal protective equipment (ppe) as specified in section 8.
- wash thoroughly after handling.
- do not eat, drink, or smoke when using this product.
- keep away from heat, sparks, open flames, and other sources of ignition.
- ground and bond containers when transferring material.
- use non-sparking tools.
conditions for safe storage, including any incompatibilities:
- store in a cool, dry, and well-ventilated area.
- keep container tightly closed.
- store away from incompatible materials (e.g., strong acids, strong oxidizing agents, halogens).
- protect from physical damage.
- store locked up.
- store in accordance with local, regional, and national regulations.
- keep away from food and beverages.

8. exposure controls/personal protection

control parameters:
- occupational exposure limits (oels): currently, there are no specific oels established for dmcha in many regions. however, general guidelines for nuisance dust or other amines may apply. consult local regulations for specific requirements. if no specific limits are available, it is recommended to maintain exposure levels as low as reasonably achievable (alara).
appropriate engineering controls:
- use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne concentrations below applicable exposure limits.
- provide eyewash stations and safety showers in areas where dmcha is handled.
individual protection measures, such as personal protective equipment (ppe):
- eye/face protection: wear chemical safety goggles and a face shield. 👀
- skin protection: wear impervious gloves (e.g., nitrile rubber, butyl rubber) and appropriate protective clothing to prevent skin contact. 🧤
- respiratory protection: if engineering controls are not sufficient to maintain airborne concentrations below exposure limits, wear a niosh-approved respirator with an organic vapor cartridge. 🫁
- thermal hazards: wear appropriate thermal protective clothing when handling dmcha at elevated temperatures.
- hygiene measures: wash hands thoroughly with soap and water after handling dmcha and before eating, drinking, smoking, or using the restroom. remove and wash contaminated clothing before reuse.

9. physical and chemical properties

property	value	unit	method	note
appearance	colorless to pale yellow liquid
odor	amine-like
odor threshold	no data available
ph	12 (1% solution)			alkaline
melting point/freezing point	-60 °c (-76 °f)	°c	astm d97
initial boiling point and boiling range	128-132 °c (262-270 °f)	°c	astm d86
flash point	27 °c (81 °f)	°c	astm d93	closed cup
evaporation rate	no data available
flammability (solid, gas)	not applicable			liquid
upper/lower flammability or explosive limits	7.1% / 1.0%	% v/v
vapor pressure	6.7 hpa (5 mmhg) at 20 °c (68 °f)	hpa
vapor density	4.39 (air = 1)
relative density	0.85 g/cm³ at 20 °c (68 °f)	g/cm³
solubility(ies)	soluble in water
partition coefficient: n-octanol/water	log pow: 1.65
auto-ignition temperature	210 °c (410 °f)	°c	din 51794
decomposition temperature	no data available
viscosity	1.2 mpa·s at 20 °c (68 °f)	mpa·s
explosive properties	no data available			may form explosive mixtures with air at elevated temperatures
oxidizing properties	no data available

10. stability and reactivity

reactivity: reacts with strong acids, strong oxidizing agents, and halogens.
chemical stability: stable under normal conditions of handling and storage.
possibility of hazardous reactions: may polymerize under specific conditions (e.g., elevated temperatures, presence of catalysts).
conditions to avoid: heat, sparks, open flames, and other sources of ignition. exposure to air and moisture.
incompatible materials: strong acids, strong oxidizing agents, halogens, isocyanates, and epoxides.
hazardous decomposition products: carbon monoxide, carbon dioxide, nitrogen oxides.

11. toxicological information

information on toxicological effects:
- acute toxicity:
  - oral ld50 (rat): 340 mg/kg (oecd test guideline 401) [ref 1]
  - dermal ld50 (rabbit): 870 mg/kg (oecd test guideline 402) [ref 2]
  - inhalation lc50 (rat): 2.8 mg/l (4 h, vapor) (oecd test guideline 403) [ref 3]
- skin corrosion/irritation: causes severe skin burns. (oecd test guideline 404) [ref 4]
- serious eye damage/eye irritation: causes serious eye damage. (oecd test guideline 405) [ref 5]
- respiratory or skin sensitization: no data available.
- germ cell mutagenicity: no evidence of mutagenicity in in vitro and in vivo studies. (oecd test guideline 471, 473, 476) [ref 6, 7, 8]
- carcinogenicity: not classified as a carcinogen by iarc, ntp, or osha.
- reproductive toxicity: no data available.
- specific target organ toxicity – single exposure: may cause respiratory irritation.
- specific target organ toxicity – repeated exposure: no data available.
- aspiration hazard: no data available.
delayed and immediate effects as well as chronic effects from short and long-term exposure:
- short-term exposure: irritation of the skin, eyes, and respiratory tract. burns to skin and eyes.
- long-term exposure: limited data available. potential for chronic respiratory effects with repeated exposure.
numerical measures of toxicity: refer to the acute toxicity values above (ld50, lc50).

12. ecological information

ecotoxicity:
- fish lc50 (oncorhynchus mykiss): 32 mg/l (96 h) (oecd test guideline 203) [ref 9]
- daphnia ec50 (daphnia magna): 52 mg/l (48 h) (oecd test guideline 202) [ref 10]
- algae erc50 (pseudokirchneriella subcapitata): 26 mg/l (72 h) (oecd test guideline 201) [ref 11]
persistence and degradability:
- biodegradability: not readily biodegradable. (oecd test guideline 301d) [ref 12]
bioaccumulative potential:
- bioaccumulation: low potential for bioaccumulation (log pow = 1.65).
mobility in soil:
- mobility: expected to have moderate mobility in soil.
other adverse effects:
- may be harmful to aquatic life with long-lasting effects.

13. disposal considerations

waste treatment methods:
- dispose of in accordance with local, regional, and national regulations.
- incineration is the preferred method of disposal.
- neutralization followed by biological treatment may be an option for dilute solutions.
- do not dispose of n the drain.
contaminated packaging:
- dispose of contaminated packaging in accordance with local, regional, and national regulations.
- empty containers should be triple-rinsed with a suitable solvent and disposed of as hazardous waste.

14. transport information

un number: un2264
un proper shipping name: dimethylcyclohexylamine
transport hazard class(es): 8
packing group: ii
environmental hazards: no
special precautions for user: refer to section 8 for personal protection.
transport in bulk according to annex ii of marpol 73/78 and the ibc code: not applicable.

15. regulatory information

safety, health and environmental regulations/legislation specific for the substance or mixture:
- globally harmonized system (ghs): classified as hazardous according to ghs criteria.
- european union: classified as hazardous according to clp regulation (ec) no 1272/2008.
- united states: subject to various regulations under tsca, sara, and osha.
- china: subject to the regulations on the control over safety of dangerous chemicals.
- other regions: consult local regulations for specific requirements.
chemical safety assessment: a chemical safety assessment may be required for this substance.

16. other information

revision date: october 26, 2023
version: 1.0
disclaimer: the information contained in this sds is based on the best available knowledge at the time of preparation. it is intended as a guide for safe handling and use of the product and is not a warranty or quality specification. users are responsible for determining the suitability of this information for their specific purposes and for complying with all applicable laws and regulations.

literature references

[ref 1] oecd (2001). oecd guidelines for the testing of chemicals, section 4. test no. 401: acute oral toxicity. organisation for economic co-operation and development, paris.
[ref 2] oecd (2002). oecd guidelines for the testing of chemicals, section 4. test no. 402: acute dermal toxicity. organisation for economic co-operation and development, paris.
[ref 3] oecd (2009). oecd guidelines for the testing of chemicals, section 4. test no. 403: acute inhalation toxicity. organisation for economic co-operation and development, paris.
[ref 4] oecd (2002). oecd guidelines for the testing of chemicals, section 4. test no. 404: acute dermal irritation/corrosion. organisation for economic co-operation and development, paris.
[ref 5] oecd (2002). oecd guidelines for the testing of chemicals, section 4. test no. 405: acute eye irritation/corrosion. organisation for economic co-operation and development, paris.
[ref 6] oecd (1997). oecd guidelines for the testing of chemicals, section 4. test no. 471: bacterial reverse mutation test. organisation for economic co-operation and development, paris.
[ref 7] oecd (2016). oecd guidelines for the testing of chemicals, section 4. test no. 473: in vitro mammalian chromosome aberration test. organisation for economic co-operation and development, paris.
[ref 8] oecd (2016). oecd guidelines for the testing of chemicals, section 4. test no. 476: in vitro mammalian cell gene mutation test. organisation for economic co-operation and development, paris.
[ref 9] oecd (2019). oecd guidelines for the testing of chemicals, section 2. test no. 203: fish, acute toxicity test. organisation for economic co-operation and development, paris.
[ref 10] oecd (2004). oecd guidelines for the testing of chemicals, section 2. test no. 202: daphnia sp. acute immobilisation test. organisation for economic co-operation and development, paris.
[ref 11] oecd (2011). oecd guidelines for the testing of chemicals, section 2. test no. 201: alga, growth inhibition test. organisation for economic co-operation and development, paris.
[ref 12] oecd (1992). oecd guidelines for the testing of chemicals, section 3. test no. 301d: ready biodegradability: closed bottle test. organisation for economic co-operation and development, paris.

this comprehensive sds provides detailed information about n,n-dimethylcyclohexylamine and emphasizes the importance of safe handling procedures and adherence to relevant regulations. remember to consult with qualified professionals and local authorities for specific guidance related to your application and location.

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