Lidocaine structural formula

Lidocaine structural formula

Structural formula

Business number 03RP
Molecular formula C14H22N2O
Molecular weight 234.34




lidocaine base,






aromatic compounds

Numbering system

CAS number:137-58-6

MDL number:MFCD00026733

EINECS number:205-302-8

RTECS number:AN7525000

BRN number:None

PubChem number:24896480

Physical property data

1. Appearance: white crystalline powder

2. Melting point (℃): 76~79

3. Solubility: easily soluble in water or ethanol, soluble in chloroform , insoluble in ether.

Toxicological data


Ecological data


Molecular structure data

1. Molar refractive index: 72.42

2. Molar volume (cm3/mol): 228.3

3. Isotonic specific volume (90.2K): 571.1

4. Surface tension (3.0 dyne/cm): 39.1

5. Polarizability (0.5 10-24cm3): 28.71

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 2

4. Number of rotatable chemical bonds: 5

5. Number of tautomers: 3

6. Topological molecule polar surface area 32.3

7. Number of heavy atoms: 17

8. Surface charge: 0

9. Complexity: 228

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability


Storage method

This product should be sealed and stored in a cool, dry place.

Synthesis method

1. Chloroacetyl chloride method

2,6-Dimethylaniline undergoes chloroacetylation with chloroacetyl chloride, then condenses with diethylamine, and then acidifies to form a salt to obtain lidocaine.

2. Diethylaminoacetic acid methyl ester method

In the presence of sodium methoxide, 2,6-dimethylaniline and N,N-diethylaminoacetic acid methyl ester are condensed, It is then acidified to form a salt to obtain the product.


Widely used for topical anesthesia, infiltration anesthesia, conduction anesthesia, and epidural anesthesia. It is also an important drug in the treatment of sudden arrhythmias.

BDMAEE:Bis (2-Dimethylaminoethyl) Ether

CAS NO:3033-62-3

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